Combinations ; See Below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Nevir | Emcure Pharmaceuticals Limited | Saicare Enterprises Ltd. | 200mg | 60 | Tablet | per tablet | KES 1,650.00 |
| Nevir | Emcure Pharmaceuticals Limited | Saicare Enterprises Ltd. | 50mg | 100ml | Suspension | per 5ML | KES 520.00 |
| Nevimune | Cipla Ltd. | Surgipharm Ltd | 200mg | 60 | Tablet | per tablet | KES 450.00 |
| Nevimune | Cipla Ltd. | Surgipharm Ltd | 50mg | 100ml | Suspension | per 5ML | KES 135.00 |
| Nevivir | Hetero Drugs Ltd | Unisel Pharma (K) Ltd. | 200mg | 60 | Tablet | per tablet | KES 460.00 |
| Neviriv | Cosmos Limited. | Cosmos Limited | 200mg | 60 | Tablet | per tablet | KES 400.00 |
| Viramune | Boehringer Ingelheim International | Laborex Kenya Eurapharma Ltd | 200mg | 60 | Tablet | per tablet | KES 2,609.00 |
| Viramune | Boehringer Ingelheim International | Laborex Kenya Eurapharma Ltd | 50mg | 240ml | Suspension | per 5ML | KES 1,812.00 |
| Nevirapine More info | |
|---|---|
| Mode Of Action | Non-nucleoside reverse transcriptase inhibitors (NNRTIs or NtRTIs) that inhibit viral reverse transcriptase and viral DNA synthesis |
| Drug Indication | HIV (in combination with other ARVs); Very useful in prevention of vertical transmission of HIV in the late pregnancy. |
| Precautions | It is rarely affected by the status of renal functions hence there may not be any need of changing the dosage in case of renal impairement unless the creatinine clearance is below 20mlL/minute; paradoxically probability of hepatoxicity. increases with the increase of CD4 counts, with more pronounced effect in women. Rifampicin reduces its plasma concentration. Known to cause serious dermatological reactions in children. The incidence for rash is reduced if introduced at a low dose and dose increased after 14 days. |
| Contra-Indications | Severe hepatic disorders (with AST or ALT levels of more than 5 times of the normal levels). |
| Side Effects | The most common side effects are rashes and body weakness. Others include: hypersensitivity reactions; serious fulminant hepatitis; Steven-Johnson syndrome; anaemia; granulocytopenia and arthralgia. |
| Dosage | Adults: 200mg OD x 2/52 then 200mg BD. Children: 2 months to 7 years; 4mg/kg OD x 2/52 then 7mg/kg BD (max. 400mg/day). 8 to 16 yrs; 4mg/kg OD x 2/52 then 7mg/kg BD (max. 400mg/day) |
| Pregnancy Category | Category B3 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Hiv Chemotherapy |